Genomewide Association Study on Fallible Behavior of Accident-Repeated Drivers in China

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Hui-qing Jin
Shu-lin Zhang
Yang Song
Wan-sheng Yu

Driving behavior of a driver is closely related to traffic accidents, and is controlled by nervous system. Gene expression in the nervous cells may indirectly affect people's behavior. In order to explore genetic basis of fallible behavior of the accident-repeated drivers, in accordance with the Chinese national standard "Physical qualifications for automobile drivers and their test protocol" (GB18463-2001), these drivers whose indexes were all abnormal were chose as candidates of case, and those whose indexes were all normal were chose as candidates of control. A total of 232 matching pairs of drivers were selected. We chose above case candidates who had three or more accidents at the level of more than equal-responsibility within 5 consecutive years (2005-2009) as case group. The control candidates who did not have liability for accidents over the same years (2005-2009) as control group, 179 matching pairs of drivers has been chosen as sample. GWAS (Genome-wide association study) are applied to 179 pairs of matching samples on fallible behavior of drivers. The result showed that 31 SNPs loci in 3 linked genes (SMAD5,TRPC7(P<10-4)and CBLN4 (P<10-5) ) are associated with fallible behavior of drivers .The current study suggested for the first time the potential association between the fallible behavior and the potential susceptible genes.

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