Effects of dextroamphetamine on simulated driving performance before and after sleep deprivation

Download
Magnus Hjälmdahl

Stimulant drugs are commonly abused and also used to promote wakefulness, yet their effects on driving performance during sleep deprivation have been poorly studied in experimental studies. We aimed to assess the effects on fundamental driving parameters during simulated driving of two doses of d-amphetamine and further to assess the interaction between d-amphetamine and sleep deprivation. A double blind, placebo controlled experiment including eighteen healthy, male volunteers was conducted.

The participants felt more alert when taking a dose of d-amphetamine than when taking placebo and the effect was stronger for the higher dose. However, the data did not show any evidence that taking d-amphetamine prevented the subjects from successively becoming sleepier during the night. A significant main effect of dose was found for three out of the five primary indicators where the lower dose lead to improved driving while the results for the higher dose were less clear. Regarding sleep deprivation, a main effect was found for four of the primary indicators and three of the secondary indicators. The results showed impaired driving in all cases but one. We found no interactions between dose and sleep deprivation.

Our results suggest that impaired driving due to fatigue is not compensated by administration of d-amphetamine. The positive effects of 10 mg was not further improved or even sustained when increasing the dose to 40 mg. This might indicate that at still higher doses commonly taken by addicts, there are few or no positive effects of d-amphetamine.

MEET US


5-6
Dec

Vision Zero for Sustainable Road Safety in the Baltic Sea Region

The conference Vision Zero for Sustainable Road Safety in the Baltic Sea Region is held i Vilnius, Lithuania. VTI is part of the organisation committé and also one of the speakers.

LATEST NEWS


2018-10-05

Users contribute to the development of train simulators

Apart from advanced driving simulators, VTI has developed several variations of train simulators which are used for training, education and research. In recent years, interest has increased drastically among major actors in the railway sector, and VTI has...


2018-10-03

VR study to contribute to a better working environment for bus drivers

A study where bus drivers test autonomous driving in a VR environment may contribute to a better working environment with reduced stress on the driver and safer driving.


2018-10-02

Non-native plant species spread via transport systems

Researchers at VTI have compiled a report on non-native invasive plant species in Sweden and how they spread via transport systems.


2018-09-20

EU-project VIRTUAL: improving road safety with virtual crash tests

Crash tests are used to improve safety on roads. Therefore the EU now funds a research project to develop virtual methods of crash testing. VTI coordinates the project, called VIRTUAL. The project now invites experts interested in Human Body Modeling to join...


2018-08-28

EU project protects cyclists and pedestrians

According to the World Health Organisation, more than one quarter of road traffic fatalities in 2010 were pedestrians and cyclists. Every year, about 335,000 unprotected road users die because of traffic accidents, which shows the scale of the problem. The EU...


2018-08-21

Swedish organisations in EU project on traffic safety and crash testing

Crash safety testing is one of the tools used to improve safety on roads. The EU is therefore funding a research project that started recently to develop virtual methods of crash testing. The long-term goal is to supplement the physical evaluation of crash...