Effects of dextroamphetamine on simulated driving performance before and after sleep deprivation

Download
Magnus Hjälmdahl

Stimulant drugs are commonly abused and also used to promote wakefulness, yet their effects on driving performance during sleep deprivation have been poorly studied in experimental studies. We aimed to assess the effects on fundamental driving parameters during simulated driving of two doses of d-amphetamine and further to assess the interaction between d-amphetamine and sleep deprivation. A double blind, placebo controlled experiment including eighteen healthy, male volunteers was conducted.

The participants felt more alert when taking a dose of d-amphetamine than when taking placebo and the effect was stronger for the higher dose. However, the data did not show any evidence that taking d-amphetamine prevented the subjects from successively becoming sleepier during the night. A significant main effect of dose was found for three out of the five primary indicators where the lower dose lead to improved driving while the results for the higher dose were less clear. Regarding sleep deprivation, a main effect was found for four of the primary indicators and three of the secondary indicators. The results showed impaired driving in all cases but one. We found no interactions between dose and sleep deprivation.

Our results suggest that impaired driving due to fatigue is not compensated by administration of d-amphetamine. The positive effects of 10 mg was not further improved or even sustained when increasing the dose to 40 mg. This might indicate that at still higher doses commonly taken by addicts, there are few or no positive effects of d-amphetamine.

LATEST NEWS


2017-11-30

Millions for research into maritime transport and the environment

Maritime transport is a major source of emissions of harmful air pollutants and carbon dioxide. In a new project, a research team from the Swedish National Road and Transport Research Institute (VTI) and the University of Gothenburg has received SEK 6.4...


2017-11-30

New research programme for more efficient travel

The Swedish National Road and Transport Research Institute (VTI) is playing an important role in a major new research programme to find radical solutions leading to fewer trips and more efficient travel, along with tools to enable better use of roads and...


2017-11-30

Simulator used to practice emergency responses safely

Emergency responses of the police, ambulance, and rescue services are associated with a high risk of accidents, but practicing them in real traffic is neither safe nor permissible. A simulator-based method developed by the Swedish National Road and Transport...


2017-10-26

Simulation of cut-in by manually driven vehicles in platooning scenarios

A study in a VTI-driving simulator has showed that a platoon will be able to handle a cut in from a manually driven car. The results of this study have recently been presented at two conferences in Japan.


2017-10-16

ERPUG Forum

The five-year anniversary of European Road Profile Users' Group (ERPUG) Forum will take place at Ramboll head quarter, Copenhagen, Denmark October 19-20, 2017.


2017-09-29

Self-driving buses in Sweden next year?

A self-driving, fossil-free bus. This idea might become reality through a forthcoming collaborative project involving the Swedish National Road and Transport Research Institute (VTI), Linköping University and several other participants. The project group aim...